Article
Extracellular and intracellular anti-mutagenic effects of bile pigments in the Salmonella typhimurium reverse mutation assay.
Toxicology in vitro : an international journal published in association with BIBRA - 1 Feb 2013
Mölzer C, Huber H, Diem K, Wallner M, Bulmer A C, Wagner K-H
Abstract excerpt
In vitro anti-genotoxic properties of bile pigments have been explored and confirmed recently. Despite these reports mechanisms to explain DNA protection by endogenous bile pigments remain unclear. Surprisingly, the quantification of cellular pigment absorption which could represent a fundamental prerequisite for intracellular (e.g., anti-mutagenic) effects, has not been explored. Therefore, we aimed to measure...
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