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Article

Identification of the human immunodeficiency virus reverse transcriptase residues that contribute to the activity of diverse nonnucleoside inhibitors.

Antimicrobial agents and chemotherapy - 1 Jul 1992

Condra J H, Emini E A, Gotlib L, Graham D J, Schlabach A J, Wolfgang J A, Colonno R J, Sardana V V

Abstract excerpt

The reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) is potently inhibited by a structurally diverse group of nonnucleoside compounds. These include pyridinone derivatives, tetrahydroimadazo[4,5,1-j,k][1,4]-benzodiazepin-2(1H)-one and -thione, and BI-RG-587 (nevirapine)....

Topics

Antiviral Agents
Azepines
Benzodiazepines
Benzoxazoles
Drug Resistance, Microbial
Escherichia coli
HIV Reverse Transcriptase
HIV-1
Humans
Imidazoles
Nevirapine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Pyridines

Pyridones

Reverse Transcriptase Inhibitors

Source

Open in PubMed Open full text

Identifiers

PMID: 1380789
DOI: 10.1128/AAC.36.7.1441
PMCID: PMC191601

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1380789-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Identification of the human immunodeficiency virus reverse transcriptase residues that contribute to the activity of diverse nonnucleoside inhibitors.PMID 1380789Read ↗

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