Article
Reduced susceptibility of human immunodeficiency virus type 1 (HIV-1) from patients with primary HIV infection to nonnucleoside reverse transcriptase inhibitors is associated with variation at novel amino acid sites.
Journal of virology - 1 Nov 2000
Brown A J, Precious H M, Whitcomb J M, Wong J K, Quigg M, Huang W, Daar E S, D'Aquila R T, Keiser P H, Connick E, Hellmann N S, Petropoulos C J, Richman D D, Little S J
Abstract excerpt
Recently, significant numbers of individuals with primary human immunodeficiency virus (HIV) infection have been found to harbor viral strains with reduced susceptibility to antiretroviral drugs. In one study, HIV from 16% of such antiretroviral-naive individuals was shown to have a susceptibility to nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) between 2.5- and 10-fold lower than that of a...
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