Article
T cell activation defect in hemodialysis patients: evidence for a role of the B7/CD28 pathway.
Kidney international - 1 Aug 1993
Girndt M, Köhler H, Schiedhelm-Weick E, Meyer zum Büschenfelde K H, Fleischer B
Abstract excerpt
The immunosuppressive effect of chronic renal failure is correlated with an impaired proliferation of peripheral blood leukocytes in vitro. This is mainly due to an impaired function of the accessory cells rather than the T cells. Here we tried to define a missing accessory signal for T cell activation in hemodialysis patients. We substituted cell surface bound molecules by adding tumor cell lines to the in vitro...
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