T cell activation defect in hemodialysis patients: evidence for a role of the B7/CD28 pathway.

doi:10.1038/ki.1993.252

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Article

T cell activation defect in hemodialysis patients: evidence for a role of the B7/CD28 pathway.

Kidney international - 1 Aug 1993

Girndt M, Köhler H, Schiedhelm-Weick E, Meyer zum Büschenfelde K H, Fleischer B

Abstract excerpt

The immunosuppressive effect of chronic renal failure is correlated with an impaired proliferation of peripheral blood leukocytes in vitro. This is mainly due to an impaired function of the accessory cells rather than the T cells. Here we tried to define a missing accessory signal for T cell acti...

Topics

3T3 Cells
Aged
Animals
Antigens, CD
Antigens, Differentiation, T-Lymphocyte
Antigens, Surface
B7-1 Antigen
Burkitt Lymphoma
CD28 Antigens
Humans
Interleukin-2
Lymphocyte Activation
Mice
Middle Aged
Monocytes
Phenotype
Phytohemagglutinins
Renal Dialysis

Source

Open in PubMed

Identifiers

PMID: 7690861
DOI: 10.1038/ki.1993.252

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7690861-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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