Article
Angiogenic macrophages produce the angiogenic inhibitor thrombospondin 1.
The American journal of pathology - 1 Sept 1993
DiPietro L A, Polverini P J
Abstract excerpt
Previous investigations have shown that macrophages play a pivotal role in the induction of angiogenesis in both physiological and pathological settings. This investigation examines the relative production of the angiogenic modulator thrombospondin-1 (TSP1) by activated and nonactivated monocytes...
Topics
- Animals
- Blotting, Northern
- Cells, Cultured
- Electrophoresis, Polyacrylamide Gel
- Humans
- Macrophages
- Membrane Glycoproteins
- Mice
- Neovascularization, Pathologic
- Phenotype
- Precipitin Tests
- RNA
- Rats
- Thrombospondins