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Article

Genetic relationships among actinomycetes that produce the immunosuppressant macrolides FK506, FK520/FK523 and rapamycin.

Journal of industrial microbiology - 1 Jan 1993

Garrity G M, Heimbuch B K, Motamedi H, Shafiee A

Abstract excerpt

A polyphasic taxonomic study was undertaken to establish the genetic and phenotypic relationships among six actinomycetes that produce the immunosuppressant macrolides FK506, FK520/FK523 and rapamycin. Chemotaxonomic studies reveal that all have Type I cell walls. Gas chromatography (GC) of fatty acid methyl esters revealed patterns consistent for strains of Streptomyces with 16:0 and 15:0 anteiso predominating....

Topics

Anti-Bacterial Agents
Chromatography, Gas
DNA Probes
DNA, Bacterial
Diaminopimelic Acid
Fatty Acids
Genes, Bacterial
Immunosuppressive Agents
Methyltransferases
Phenotype
Polyenes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Homology, Nucleic Acid

Sirolimus

Streptomyces

Tacrolimus

Source

Identifiers

PMID: 7688970
DOI: 10.1007/BF01570127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7688970-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Genetic relationships among actinomycetes that produce the immunosuppressant macrolides FK506, FK520/FK523 and rapamycin.PMID 7688970Read ↗

Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520Semantic proximity Read ↗

Structural Organization of A Multifunctional Polyketide Synthase Involved in the Biosynthesis of the Macrolide Immunosuppressant FK506Semantic proximity Read ↗

Enhancement of FK520 production in Streptomyces hygroscopicus var. ascomyceticus ATCC 14891 by overpressing the pathyway specific regulatory gene fkbR2Semantic proximity Read ↗

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.Semantic proximity Read ↗

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Roles of fkbN in positive regulation and tcs7 in negative regulation of FK506 biosynthesis in Streptomyces sp. strain KCTC 11604BP.Semantic proximity Read ↗

Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismateSemantic proximity Read ↗

The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender unitsSemantic proximity Read ↗

Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)Semantic proximity Read ↗

FK506 Maturation Involves a Cytochrome P450 Protein-Catalyzed Four-Electron C-9 Oxidation in Parallel with a C-31<i>O</i>-MethylationSemantic proximity Read ↗

Mutational biosynthesis of tacrolimus analogues by fkbO deletion mutant of Streptomyces sp. KCTC 11604BP.Semantic proximity Read ↗

Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor.Semantic proximity Read ↗

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