Article
A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon.
The EMBO journal - 1 Aug 1993
Hassel B A, Zhou A, Sotomayor C, Maran A, Silverman R H
Abstract excerpt
2-5A-dependent RNase is the terminal factor in the interferon-regulated 2-5A system thought to function in both the molecular mechanism of interferon action and in the general control of RNA stability. However, direct evidence for specific functions of 2-5A-dependent RNase has been generally lack...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Cell Division
- Cells, Cultured
- Cloning, Molecular
- Encephalomyocarditis virus
- Endoribonucleases
- Enzyme Induction
- Genes, Dominant
- Humans
- Interferons
- Mice
- Molecular Sequence Data
- Mutation
- Protein Kinases
- Sequence Homology, Amino Acid
- Virus Replication