Article
Resistance to spiramycin in Streptomyces ambofaciens, the producer organism, involves at least two different mechanisms.
Journal of general microbiology - 1 May 1993
Pernodet J L, Alegre M T, Blondelet-Rouault M H, Guérineau M
Abstract excerpt
During its stationary phase, Streptomyces ambofaciens produces the macrolide antibiotic spiramycin, and has to protect itself against this antibiotic. Young mycelia, not yet producing spiramycin, are sensitive to it, but they become fully resistant when production begins. In a sensitive mycelium,...
Topics
- Anti-Bacterial Agents
- Drug Resistance, Microbial
- Mutation
- Protein Biosynthesis
- RNA, Bacterial
- RNA, Ribosomal, 23S
- Spiramycin
- Streptomyces