Article
Serologic and molecular studies of two kindreds expressing recombinant HLA DR1/DR2 haplotypes.
Tissue antigens - 1 Mar 1993
Wisecarver J, Shepherd S, Beisel K, Rubocki R
Abstract excerpt
We have recently identified two unrelated kindreds in which DR1 and DR2 co-segregate as a single haplotype spanning several generations. Serology, PCR-RFLP and sequence-specific oligonucleotide probes were used to characterize the presence and segregation of the DRB1 and DRB5 loci in these two ki...
Topics
- Alleles
- Base Sequence
- DNA Probes, HLA
- Epitopes
- Female
- Genes, MHC Class II
- HLA-DR Antigens
- HLA-DR1 Antigen
- HLA-DR2 Antigen
- HLA-DRB1 Chains
- HLA-DRB5 Chains
- Haplotypes
- Histocompatibility Antigens Class II
- Humans
- Male
- Molecular Sequence Data
- Pedigree
- Polymerase Chain Reaction