Article
The absence of DR51 in a DRB5-positive individual DR2ES is caused by a null allele (DRB5*0108N)
Tissue antigens - 1 Oct 1997
Voorter C E, Roeffaers H E, du Toit E D, van den Berg-Loonen E M
Abstract excerpt
DR51, a protein encoded by the DRB5 gene, was shown to be present in almost all DR2-positive haplotypes. Exceptions were reported, some DR2-negative samples were shown to be DR51 positive and in a number of DR2-positive samples no DR51 antigen could be demonstrated. In some of them lack of the DR...
Topics
- Alleles
- Base Sequence
- DNA, Complementary
- Genes, MHC Class II
- Genotype
- HLA-DR Antigens
- HLA-DR2 Antigen
- HLA-DRB5 Chains
- Haplotypes
- Humans
- Linkage Disequilibrium
- Lymphocytes
- Molecular Sequence Data
- Phenotype
- RNA, Messenger
- Sequence Alignment
- Sequence Analysis, DNA
- Sequence Homology