Severity differences in beta-thalassaemia/haemoglobin E syndromes: implication of genetic factors.

doi:10.1111/j.1365-2141.1993.tb04702.x

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Article

Severity differences in beta-thalassaemia/haemoglobin E syndromes: implication of genetic factors.

British journal of haematology - 1 Apr 1993

Winichagoon P, Thonglairoam V, Fucharoen S, Wilairat P, Fukumaki Y, Wasi P

Abstract excerpt

Genetic factors determining the difference in severity of anaemia in beta-thalassaemia/HbE disease were studied in 90 patients who had haemoglobin levels, at steady state, ranging from 4.2 to 12.6 g/dl. Co-inheritance of alpha-thalassaemia 2 and haemoglobin Constant Spring could significantly dec...

Topics

Adolescent
Adult
Base Sequence
Fetal Hemoglobin
Globins
Haplotypes
Hemoglobin E
Humans
Middle Aged
Molecular Sequence Data
Mutation
Polymorphism, Genetic
beta-Thalassemia

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