Effect of alpha thalassaemia trait and enhanced gamma chain production on disease severity in beta thalassaemia major and intermedia.

doi:10.1136/adc.70.1.30

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Article

Effect of alpha thalassaemia trait and enhanced gamma chain production on disease severity in beta thalassaemia major and intermedia.

Archives of disease in childhood - 1 Jan 1994

Gringras P, Wonke B, Old J, Fitches A, Valler D, Kuan A M, Hoffbrand V

Abstract excerpt

One hundred and twenty patients with homozygous beta thalassaemia were selected to determine the clinical effects of certain genetic factors which may modify disease severity. Genetic analysis defined specific beta thalassaemia mutations, the alpha thalassaemia genotype, and the presence of an Xm...

Topics

Adolescent
Adult
Blood Transfusion
Blotting, Southern
Deferoxamine
Female
Fetal Hemoglobin
Gene Deletion
Genotype
Humans
Male
Mutation
Polymerase Chain Reaction
Prognosis
Puberty, Delayed
alpha-Thalassemia
beta-Thalassemia
gamma-Globulins

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Identifiers

PMID: 7509151
DOI: 10.1136/adc.70.1.30
PMCID: PMC1029678

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7509151-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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