Article
Effect of hydroxyurea on the transfusion requirements in patients with severe HbE-beta-thalassaemia: a genotypic and phenotypic study.
Journal of clinical pathology - 1 Feb 2010
Italia Khushnooma Y, Jijina Farah F, Merchant Rashid, Panjwani Sangeeta, Nadkarni Anita H, Sawant Pratibha M, Nair Sona B, Ghosh Kanjaksha, Colah Roshan B
Abstract excerpt
BACKGROUND: Haemoglobin E (HbE)-beta-thalassaemia has a very variable clinical presentation. The management of severe cases that are often transfusion dependent is similar to that of cases of beta-thalassaemia major; however, this is often not possible in India because of its high cost and the lack of availability of safe blood at many places. Thus there was a need for a drug such as hydroxyurea, which is known...
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