Association of Xmn1 -158 γG variant with severity and HbF levels in β-thalassemia major and sickle cell anaemia.

Abstract excerpt

Haemoglobinopathies including β-thalassemia and sickle cell anaemia (SCA) are considered to be classical monogenic diseases. There is considerable clinical variability between patients inheriting identical β-globin mutations. The reasons for this variability are not well understood. Previous studies have suggested that a variety of genetic determents influence different clinical phenotypes. The genetic variants...

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