Breakpoint clusters of the <i>PML</i> gene in acute promyelocytic leukemia: Primary structure of the reciprocal products of the <i>PML‐RARA</i> gene in a patient with t(15;17)

Abstract excerpt

DNA studies of the translocation t(15;17) in acute promyelocytic leukemia (APL) have shown that the retinoic acid receptor alpha (RARA) gene on chromosome 17 is juxtaposed to the promyelocytic leukemia (PML) gene on chromosome 15. The PML breakpoints have been mapped to 3 clusters: bcr1, bcr2, and bcr3. We have examined the PML breakpoint distribution in a series of 33 Chinese patients with APL. Twenty-two...

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