Article
Production and characterization of lymphoblastoid cell lines with the paroxysmal nocturnal hemoglobinuria phenotype.
Blood - 1 Jan 1993
Hillmen P, Bessler M, Crawford D H, Luzzatto L
Abstract excerpt
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic disorder caused by a somatic mutation in a hematopoietic stem cell. The fact that, in some cases, not only myeloid but also lymphoid cells are affected suggests that the mutation has occurred in a multipotent stem cell. By studying the expression of CD59 antigen (membrane inhibitor of reactive lysis) and of decay accelerating factor (DAF) on the...
Topics
- Adult
- Aged
- Antigens, CD
- Antigens, CD19
- Antigens, Differentiation, B-Lymphocyte
- B-Lymphocytes
- CD48 Antigen
- CD55 Antigens
- CD59 Antigens
- Cell Line, Transformed
- Complement Inactivator Proteins