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Article

PIG-A, DAF and proto-oncogene expression in paroxysmal nocturnal haemoglobinuria-associated acute myelogenous leukaemia blasts.

British journal of haematology - 1 Jan 1995

Stafford H A, Nagarajan S, Weinberg J B, Medof M E

Abstract excerpt

Failed surface expression of the complement decay-accelerating factor (DAF) due to mutation of the PIG-A gene is a hallmark of affected paroxysmal nocturnal haemoglobinuria (PNH) blood elements. Previous findings that acute myelogenous leukaemia (AML) blasts evolving in a PNH patient differed from idiopathic AML blasts in that they exhibited DAF negativity suggested that the leukaemic blasts derived from an...

Topics

Antigens, CD
Base Sequence
Blotting, Southern
CD55 Antigens
Cell Transformation, Neoplastic
Complement Inactivator Proteins
Follow-Up Studies
Gene Expression
Hemoglobinuria, Paroxysmal
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia, Myeloid, Acute

Membrane Glycoproteins

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

Precancerous Conditions

Proto-Oncogene Mas

Proto-Oncogenes

Source

Identifiers

PMID: 7530480
DOI: 10.1111/j.1365-2141.1995.tb08908.x

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7530480-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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PIG-A, DAF and proto-oncogene expression in paroxysmal nocturnal haemoglobinuria-associated acute myelogenous leukaemia blasts.PMID 7530480Read ↗

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Mutations in the PIG-A gene causing paroxysmal nocturnal hemoglobinuria are mainly of the frameshift typeSemantic proximity Read ↗

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