Article
New HLA-DPB1 alleles generated by interallelic gene conversion detected by analysis of sperm.
Nature genetics - 1 Aug 1995
Zangenberg G, Huang M M, Arnheim N, Erlich H
Abstract excerpt
The rate at which allelic diversity at the HLA loci evolves has been the subject of considerable controversy. The patchwork pattern of sequence polymorphism within the second exon of the HLA class II loci, particularly in the DPB1 locus, may have been generated by segmental exchange (gene conversion). We have analysed the frequency of variant DPB1 sequences that have been created by interallelic gene conversion...
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