Article
The role of the Val353 residue in antagonist binding to rat CCK-B receptors.
Neuroreport - 19 Jun 1995
Malatynska E, Knapp R J, Stropova D, Varga E, Yamamura H I
Abstract excerpt
The Val353 residue of the rat cholecystokinin-B (CCK-B) receptor was mutated to Leu to test whether this residue is part of a binding site for antagonists having different chemical structures. The agonist radioligand [3H]SNF 8702 showed similar affinity for both wild-type and mutant receptors. Mu...
Topics
- Amino Acids
- Animals
- Binding, Competitive
- Dose-Response Relationship, Drug
- Mutation
- Peptide Fragments
- Peptoids
- Rats
- Rats, Inbred Strains
- Receptors, Cholecystokinin
- Sincalide
- Valine