Article
Evidence that the ancestral haplotype in Australian hemochromatosis patients may be associated with a common mutation in the gene.
American journal of human genetics - 1 Aug 1995
Crawford D H, Powell L W, Leggett B A, Francis J S, Fletcher L M, Webb S I, Halliday J W, Jazwinska E C
Abstract excerpt
Hemochromatosis (HC) is a common inherited disorder of iron metabolism for which neither the gene nor biochemical defect have yet been identified. The aim of this study was to look for clinical evidence that the predominant ancestral haplotype in Australian patients is associated with a common mutation in the gene. We compared indices of iron metabolism and storage in three groups of HC patients categorized...
Topics
- Adult
- Aged
- Analysis of Variance
- Australia
- Female
- Haplotypes
- Hemochromatosis
- Heterozygote
- Humans
- Iron
- Male
- Middle Aged