Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased risk of pancreatic cancer in melanoma-prone kindreds with p16INK4 mutations.

The New England journal of medicine - 12 Oct 1995

Goldstein A M, Fraser M C, Struewing J P, Hussussian C J, Ranade K, Zametkin D P, Fontaine L S, Organic S M, Dracopoli N C, Clark W H

Abstract excerpt

BACKGROUND: A gene on chromosome 9p, p16INK4, has been implicated in the pathogenesis of cutaneous malignant melanoma in 19 melanoma-prone families. In 10 of these kindreds mutations that impaired the function of the p16INK4 protein (p16M alleles) cosegregated with the disease. By contrast, in the other nine kindreds the mutation did not alter the function of p16INK4 (p16W alleles). We looked for differences in...

Topics

Adult
Alleles
Chromosomes, Human, Pair 9
Female
Genetic Predisposition to Disease
Humans
Male
Melanoma
Mutation
Neoplastic Syndromes, Hereditary
Pancreatic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pedigree

Prospective Studies

Risk

Skin Neoplasms

Source

Identifiers

PMID: 7666916
DOI: 10.1056/NEJM199510123331504

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7666916-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased risk of pancreatic cancer in melanoma-prone kindreds with p16INK4 mutations.PMID 7666916Read ↗

Genotype-phenotype relationships in U.S. melanoma-prone families with CDKN2A and CDK4 mutations.Semantic proximity Read ↗

Genotype-phenotype correlations for pancreatic cancer risk in Dutch melanoma families with pathogenic CDKN2A variants.Semantic proximity Read ↗

Risk of developing pancreatic cancer in families with familial atypical multiple mole melanoma associated with a specific 19 deletion ofp16 (p16-Leiden)Semantic proximity Read ↗

Increased risk of cancer other than melanoma in CDKN2A founder mutation (p16-Leiden)-positive melanoma families.Semantic proximity Read ↗

Risk of developing pancreatic cancer in families with familial atypical multiple mole melanoma associated with a specific 19 deletion of p16 p16LeidenSemantic proximity Read ↗

Risk of developing pancreatic cancer in families with familial atypical multiple mole melanoma associated with a specific 19 deletion of p16 (p16-Leiden).Semantic proximity Read ↗

CDKN2A germline mutations in familial pancreatic cancer.Semantic proximity Read ↗

High frequency of multiple melanomas and breast and pancreas carcinomas in CDKN2A mutation-positive melanoma families.Semantic proximity Read ↗

Variants associated with susceptibility to pancreatic cancer and melanoma do not reciprocally affect risk.Semantic proximity Read ↗

Pancreatic cancer-associated gene polymorphisms in a nation-wide cohort of p16-Leiden germline mutation carriers; a case-control study.Semantic proximity Read ↗

INK4/ARF germline alterations in pancreatic cancer patients.Semantic proximity Read ↗

Prevalence of CDKN2A mutations in pancreatic cancer patients: implications for genetic counseling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.