Article
Pancreatic cancer-associated gene polymorphisms in a nation-wide cohort of p16-Leiden germline mutation carriers; a case-control study.
BMC research notes - 26 Jun 2015
Potjer Thomas P, van der Stoep Nienke, Houwing-Duistermaat Jeanine J, Konings Ingrid C A W, Aalfs Cora M, van den Akker Peter C, Ausems Margreet G, Dommering Charlotte J, van der Kolk Lizet E, Maiburg Merel C, Spruijt Liesbeth, Wagner Anja, Vasen Hans F A, Hes Frederik J
Abstract excerpt
BACKGROUND: The p16-Leiden founder mutation in the CDKN2A gene is the most common cause of Familial Atypical Multiple Mole Melanoma (FAMMM) syndrome in the Netherlands. Individuals with this mutation are at increased risk for developing melanoma of the skin, as well as pancreatic cancer. However, there is a notable interfamilial variability in the occurrence of pancreatic cancer among p16-Leiden families. We...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Case-Control Studies
- Cyclin-Dependent Kinase Inhibitor p16
- Dysplastic Nevus Syndrome
- Female
- Germ-Line Mutation