INK4/ARF germline alterations in pancreatic cancer patients.

doi:10.1093/annonc/mdg498

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Article

INK4/ARF germline alterations in pancreatic cancer patients.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jan 2004

Ghiorzo P, Pastorino L, Bonelli L, Cusano R, Nicora A, Zupo S, Queirolo P, Sertoli M, Pugliese V, Bianchi-Scarrà G

Abstract excerpt

BACKGROUND: Roughly 40% of germinal mutations in melanoma families (MF) affect p16(INK4a) and p14(ARF). We investigated the association between INK4/ARF alterations and the occurrence of pancreatic cancer in MF and in sporadic pancreatic cancer (SPC) patients. PATIENTS AND METHODS: Forty-nine MF, 66 SPC cases and 54 controls were enrolled. The INK4/ARF locus was screened. RESULTS: As compared with the general...

Topics

Adenocarcinoma
Adolescent
Adult
Aged
Aged, 80 and over
DNA Mutational Analysis
Female
Genes, p16
Genetic Predisposition to Disease
Germ-Line Mutation
Heterozygote
Humans
Incidence
Male

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Melanoma

Middle Aged

Molecular Sequence Data

Pancreatic Neoplasms

Source

Open in PubMed

Identifiers

PMID: 14679123
DOI: 10.1093/annonc/mdg498

Provenance

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