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Article

Human cytomegalovirus neutralizing antibody-resistant phenotype is associated with reduced expression of glycoprotein H.

Journal of virology - 1 Oct 1995

Li L, Coelingh K L, Britt W J

Abstract excerpt

We have characterized a neutralizing antibody-resistant mutant human cytomegalovirus (HCMV) obtained from a patient treated with a human monoclonal antiglycoprotein H (gH; unique long region 75) antibody. This virus exhibited resistance to several different neutralizing anti-gH murine monoclonal antibodies (MAbs), as well as to a polyvalent anti-gH serum. The resistant phenotype was unstable and could be...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Antibodies, Viral
Cells, Cultured
Cytomegalovirus
Gene Expression
Genes, Viral
Humans
Male
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neutralization Tests

Phenotype

Sequence Homology, Amino Acid

Skin

Viral Envelope Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7666509
DOI: 10.1128/JVI.69.10.6047-6053.1995
PMCID: PMC189501

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7666509-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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