Article
Glycoprotein N subtypes of human cytomegalovirus induce a strain-specific antibody response during natural infection.
The Journal of general virology - 1 Aug 2009
Burkhardt Christiane, Himmelein Susanne, Britt William, Winkler Thomas, Mach Michael
Abstract excerpt
Human cytomegalovirus (HCMV) encodes several highly polymorphic envelope glycoproteins; however, the biological relevance of this polymorphism is unclear. Glycoprotein N (gN) is one member of this polymorphic protein family. Four major gN genotypes (gN1-4) have been identified. We have tested the hypothesis that the gN polymorphism represents a mechanism to evade a neutralizing antiviral antibody response. Four...
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