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Article

Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C

8 Sept 1995

Abstract excerpt

Germ-line mutations of the von Hippel-Lindau tumor suppressor gene (VHL) predispose individuals to a variety of human tumors, and somatic mutations of this gene have been identified in sporadic renal cell carcinomas and cerebellar hemangioblastomas. Two transcriptional elongation factors, Elongin B and C, were shown to bind in vitro and in vivo to a short, colinear region of the VHL protein (pVHL) that is...

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Identifiers

PMID: 7660130
DOI: 10.1126/science.7660130

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and CPMID 7660130Read ↗

Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein.Semantic proximity Read ↗

Inhibition of transcription elongation by the VHL tumor suppressor protein.Semantic proximity Read ↗

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene.Semantic proximity Read ↗

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteinsSemantic proximity Read ↗

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.Semantic proximity Read ↗

VHL mutations linked to type 2C von Hippel-Lindau disease cause extensive structural perturbations in pVHL.Semantic proximity Read ↗

von Hippel-Lindau DiseaseSemantic proximity Read ↗

The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity.Semantic proximity Read ↗

Renal cell carcinoma- and pheochromocytoma-specific altered gene expression profiles in VHL mutant clones.Semantic proximity Read ↗

Novel genetic characterisation and phenotype correlation in von Hippel-Lindau (VHL) disease based on the Elongin C binding site: a large retrospective study.Semantic proximity Read ↗

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex.Semantic proximity Read ↗

Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila.Semantic proximity Read ↗

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