Article
A high molecular weight melanoma-associated antigen-specific chimeric antigen receptor redirects lymphocytes to target human melanomas.
Cancer research - 15 Apr 2010
Burns William R, Zhao Yangbing, Frankel Timothy L, Hinrichs Christian S, Zheng Zhili, Xu Hui, Feldman Steven A, Ferrone Soldano, Rosenberg Steven A, Morgan Richard A
Abstract excerpt
Immunotherapy, particularly the adoptive cell transfer (ACT) of tumor-infiltrating lymphocytes (TIL), is a very promising therapy for metastatic melanoma. Some patients unable to receive TIL have been successfully treated with autologous peripheral blood lymphocytes (PBL), genetically modified to express human leukocyte antigen (HLA) class I antigen-restricted, melanoma antigen-reactive T-cell receptors; however,...
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