Article
Otitis media incidence and impact on the auditory brain stem response in lipopolysaccharide-nonresponsive C3H/HeJ mice.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery - 1 Nov 1997
Mitchell C R, Kempton J B, Scott-Tyler B, Trune D R
Abstract excerpt
Although mice of the C3H strain normally respond to bacterial lipopolysaccharide with appropriate immune system activation, mice of the C3H/HeJ substrain do not because of a gene defect. This suggests they may be more susceptible to opportunistic bacterial infections and more likely to have otiti...
Topics
- Age Factors
- Animals
- Audiometry, Pure-Tone
- Auditory Threshold
- Bacterial Infections
- Disease Models, Animal
- Disease Susceptibility
- Evoked Potentials, Auditory, Brain Stem
- Genetic Predisposition to Disease
- Hearing
- Hearing Loss, Conductive
- Incidence
- Lipopolysaccharides
- Mice