Article
Genotypic detection of Mycobacterium tuberculosis rifampin resistance: comparison of single-strand conformation polymorphism and dideoxy fingerprinting.
Journal of clinical microbiology - 1 Jun 1995
Felmlee T A, Liu Q, Whelen A C, Williams D, Sommer S S, Persing D H
Abstract excerpt
Detection of mutations in the rpoB gene of Mycobacterium tuberculosis can be used as an accurate predictor of rifampin resistance in the majority of strains tested. Simple but highly accurate screening methods must be developed for the detection of these mutations. Either DNA sequence analysis or...
Topics
- DNA Fingerprinting
- DNA, Bacterial
- DNA, Single-Stranded
- Drug Resistance, Microbial
- Evaluation Studies as Topic
- Genes, Bacterial
- Genotype
- Humans
- Mutation
- Mycobacterium tuberculosis
- Nucleic Acid Conformation
- Polymorphism, Genetic
- Rifampin