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Bone marrow-derived mesenchymal stem cells differentiate into nerve-like cells in vitro after transfection with brain-derived neurotrophic factor gene.

In vitro cellular & developmental biology. Animal - 1 Mar 2015

Liu Qianxu, Cheng Guangui, Wang Zhiwei, Zhan Shujie, Xiong Binbin, Zhao Xiaoming

Abstract excerpt

Bone marrow-derived mesenchymal stem cells can differentiate into a variety of adult cells. Brain-derived neurotrophic factor (BDNF) is briefly active during differentiation and induces mesenchymal stem cells to differentiate into nerve cells. In this study, we cloned human BDNF to generate a recombinant pcDNA3.1(-)-BDNF vector and transfected the vector into bone marrow-derived mesenchymal stem cells. We...

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Identifiers

PMID: 25773996
DOI: 10.1007/s11626-015-9875-1
PMCID: PMC4368845

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BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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