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Article

Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts

1 Jan 2015

Abstract excerpt

The relationship between oxidative stress and miRNA changes in placenta as a potential mechanism involved in preeclampsia (PE) is not fully elucidated. We investigated the impact of oxidative stress on miRNAs and mRNA expression profiles of genes associated with PE in villous 3A first trimester trophoblast cells exposed to H2O2 at 12 different concentrations (0-1 mM) for 0.5, 4, 24, and 48 h. Cytotoxicity,...

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PMID: 26339600
DOI: 10.1155/2015/257090

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