Article
The antigen processing-associated transporter gene polymorphism: Role on gene and protein expression in HPV-infected pre-cancerous cervical lesion.
Frontiers in cellular and infection microbiology - 1 Jan 2022
Medeiros Fernanda Silva, da Silva Mauro César, da Silva Neila Caroline Henrique, Gomes Thailany Thays, Gomes Renan Garcia, Paiva Larissa Albuquerque, Dos Santos Gomes Fabiana Oliveira, Peixoto Christina Alves, Rygaard Maria Carolina Valença, Welkovic Stefan, Menezes Maria Luiza Bezerra, Donadi Eduardo Antônio, Lucena-Silva Norma
Abstract excerpt
Human papillomavirus (HPV) is the major pathogen for cervical lesions. The evasion mechanism of the immune response and persistence of HPV infection can be influenced by polymorphisms (SNPs) in genes associated with transporter associated with antigen processing (TAP), which may change the peptide binding affinity or the TAP expression impacting the efficiency of peptide transport in the secretory pathway, and...
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