Cytochrome P4502D6 genotype does not determine response to clozapine.

doi:10.1111/j.1365-2125.1995.tb04471.x

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Article

Cytochrome P4502D6 genotype does not determine response to clozapine.

British journal of clinical pharmacology - 1 Apr 1995

Arranz M J, Dawson E, Shaikh S, Sham P, Sharma T, Aitchison K, Crocq M A, Gill M, Kerwin R, Collier D A

Abstract excerpt

1. The atypical antipsychotic drug clozapine, used in the treatment of resistant schizophrenia, is metabolized partly by the hepatic cytochrome P450 enzyme CYP2D6. Two phenotypes with respect to the activity of the enzyme are recognized (extensive metabolisers (EM) and poor metabolisers (PM)), resulting from allelic variation in the gene, CYP2D6. 2. Genotype was determined in 123 schizophrenic patients currently...

Topics

Alleles
Clozapine
Cytochrome P-450 CYP1A2
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Female
Gene Frequency
Genotype
Homozygote
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mixed Function Oxygenases

Mutation

Oxidoreductases

Polymerase Chain Reaction

Regression Analysis

Schizophrenia

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Identifiers

PMID: 7640149
DOI: 10.1111/j.1365-2125.1995.tb04471.x
PMCID: PMC1365130

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7640149-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Cytochrome P4502D6 genotype does not determine response to clozapine.PMID 7640149Read ↗

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