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Article

Cytochrome P450 2D6 genotype does not predict SSRI (fluoxetine or paroxetine) induced hyponatraemia.

Human psychopharmacology - 1 Jun 2002

Stedman Catherine A M, Begg Evan J, Kennedy Martin A, Roberts Rebecca, Wilkinson Timothy J

Abstract excerpt

AIMS: The aims of this study were to determine if patients with SSRI-related hyponatraemia were (1) genetically poor metabolizers of CYP2D6, and/or (2) had excessive plasma concentrations of the SSRI antidepressant. METHODS: Plasma DNA from 20 people with hyponatraemia attributable to fluoxetine or paroxetine was analysed for the CYP2D6 alleles *1-*16. Trough plasma concentrations of fluoxetine and norfluoxetine,...

Topics

Aged
Aged, 80 and over
Cytochrome P-450 CYP2D6
Depressive Disorder
Female
Fluoxetine
Genotype
Humans
Hyponatremia
Male
Middle Aged
Paroxetine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Factors

Selective Serotonin Reuptake Inhibitors

Source

Identifiers

PMID: 12404686
DOI: 10.1002/hup.394

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Cytochrome P450 2D6 genotype does not predict SSRI (fluoxetine or paroxetine) induced hyponatraemia.PMID 12404686Read ↗

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