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Article

Unidentified CYP2D6 genotype does not affect pharmacological treatment for patients with first episode psychosis.

Journal of psychopharmacology (Oxford, England) - 1 Dec 2024

De Brabander Emma Y, van Amelsvoort Thérèse, van Westrhenen Roos

Abstract excerpt

BACKGROUND: Research on the pharmacogenetic influence of hepatic CYP450 enzyme 2D6 (CYP2D6) on metabolism of drugs for psychosis and associated outcome has been inconclusive. Some results suggest increased risk of adverse reactions in poor and intermediate metabolizers, while others find no relationship. However, retrospective designs may fail to account for the long-term pharmacological treatment of patients....

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Identifiers

PMID: 39344086
DOI: 10.1177/02698811241279022
PMCID: PMC11528939

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