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Article

The association between CYP2D6 genotype and switching antipsychotic medication to clozapine.

European journal of clinical pharmacology - 1 Nov 2013

Gregoor Jochem G, van der Weide Karen, van der Weide Jan, van Megen Harold J G M, Egberts Antoine C G, Heerdink Eibert R

Abstract excerpt

PURPOSE: Genetic variation in the cytochrome P450 2D6 (CYP2D6) enzyme is responsible for interindividual differences in the metabolism of many antipsychotic drugs, but the clinical relevance of polymorphisms in CYP2D6 for response to antipsychotic treatment is relatively unknown. In the Netherlands, clozapine is prescribed only when patients are non-responsive to or intolerant of at least two different...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23831869
DOI: 10.1007/s00228-013-1553-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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