Article
Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1995
Fukuda T, Kitamura D, Taniuchi I, Maekawa Y, Benhamou L E, Sarthou P, Watanabe T
Abstract excerpt
The HS1 protein is one of the major substrates of non-receptor-type protein-tyrosine kinases and is phosphorylated immediately after crosslinking of the surface IgM on B cells. The mouse B-lymphoma cell line WEHI-231 is known to undergo apoptosis upon crosslinking of surface IgM by anti-IgM antib...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Apoptosis
- Blood Proteins
- Gene Expression
- Genetic Variation
- Humans
- Immunoglobulin M
- Lymphoma, B-Cell
- Mice
- Protein-Tyrosine Kinases
- Receptors, Antigen, B-Cell
- Signal Transduction
- Substrate Specificity