Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans.

doi:10.1172/JCI118111

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Article

Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans.

The Journal of clinical investigation - 1 Aug 1995

Caulfield M, Lavender P, Newell-Price J, Farrall M, Kamdar S, Daniel H, Lawson M, De Freitas P, Fogarty P, Clark A J

Abstract excerpt

The renin-angiotensin system regulates blood pressure and sodium balance. The angiotensinogen gene which encodes the key substrate within this system has been linked to essential hypertension in White Europeans. It has been suggested that people of West African ancestry may have a different genetic basis for hypertension. In this study we have tested whether there is linkage of the angiotensinogen gene to...

Topics

Adult
Africa
Aged
Alcohol Drinking
Alleles
Angiotensinogen
Black People
Blood Glucose
Body Mass Index
Female
Genetic Linkage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Hypertension

Male

Middle Aged

Nuclear Family

Oligonucleotides

Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7635961
DOI: 10.1172/JCI118111
PMCID: PMC185250

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7635961-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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