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Article

Differential distribution of genes encoding the virulence factor trans-sialidase along Trypanosoma cruzi Discrete typing units.

PloS one - 1 Jan 2013

Burgos Juan M, Risso Marikena G, Brenière Simone Frédérique, Barnabé Christian, Campetella Oscar, Leguizamón María Susana

Abstract excerpt

Trypanosoma cruzi the agent of Chagas disease is a monophyletic but heterogeneous group conformed by several Discrete Typing Units (DTUs) named TcI to TcVI characterized by genetic markers. The trans-sialidase (TS) is a virulence factor involved in cell invasion and pathogenesis that is differentially expressed in aggressive and less virulent parasite stocks. Genes encoding TS-related proteins are included in a...

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PMID: 23536842
DOI: 10.1371/journal.pone.0058967
PMCID: PMC3594200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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