Article
Promoter-specific regulation of gene expression by an exogenously added homedomain that promotes neurite growth.
FEBS letters - 17 Jul 1995
Le Roux I, Duharcourt S, Volovitch M, Prochiantz A, Ronchi E
Abstract excerpt
pAntp, a 60 amino acid long peptide corresponding to the homeodomain of the Drosophila Antennapedia protein, translocates through neuronal membranes when added exogenously to neurons in culture, where it accumulates in the nucleus and promotes neurite outgrowth. We proposed that the peptide, once internalized, may compete for homeoprotein DNA binding sites. To investigate this point, we have produced a permanent...
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