Article
Identification of apolipoprotein B100 polymorphisms that affect low-density lipoprotein metabolism: description of a new approach involving monoclonal antibodies and dynamic light scattering.
Biochemistry - 25 Jul 1995
Chatterton J E, Schlapfer P, Bütler E, Gutierrez M M, Puppione D L, Pullinger C R, Kane J P, Curtiss L K, Schumaker V N
Abstract excerpt
Rare mutations in apolipoprotein B (apoB) can cause defective binding of low-density lipoproteins (LDLs) to the LDL receptor, leading to elevated plasma cholesterol levels and premature atherosclerosis. This communication describes a novel approach to study the effects of apoB mutations on LDL metabolism. Monoclonal antibody MB19 identifies a common polymorphism in apoB, an Ile/Thr substitution at residue 71, by...
Topics
- Alleles
- Antibodies, Monoclonal
- Apolipoprotein B-100
- Apolipoproteins B
- Genetic Carrier Screening
- Genotype
- Heterozygote
- Humans
- Light
- Lipoproteins, LDL