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The Rsu-1-PINCH1-ILK complex is regulated by Ras activation in tumor cells

24 Apr 2008

Abstract excerpt

The link between Ras transformation and enhanced cell migration due to altered integrin signaling is well established in tumorigenesis, however there remain gaps in our understanding of its mechanism. The Ras suppressor, Rsu-1, has recently been linked to the IPP (integrin-linked kinase {ILK}, PINCH-1/LIMS1, parvin) focal adhesion complex based on its interaction with the LIM 5 domain of PINCH1. Defining the role...

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PMID: 18436335
DOI: 10.1016/j.ejcb.2008.02.011

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