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Article

Mutations in a peptidylprolyl-cis/trans-isomerase gene lead to a defect in 3'-end formation of a pre-mRNA in Saccharomyces cerevisiae.

The Journal of biological chemistry - 1 Jan 1999

Hani J, Schelbert B, Bernhardt A, Domdey H, Fischer G, Wiebauer K, Rahfeld J U

Abstract excerpt

In a genetic screen aimed at the identification of trans-acting factors involved in mRNA 3'-end processing of budding yeast, we have previously isolated two temperature-sensitive mutants with an apparent defect in the 3'-end formation of a plasmid-derived pre-mRNA. Surprisingly, both mutants were rescued by the essential gene ESS1/PTF1 that encoded a putative peptidylprolyl-cis/trans-isomerase (PPIase) (Hani, J.,...

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PMID: 9867817
DOI: 10.1074/jbc.274.1.108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Mutations in a peptidylprolyl-cis/trans-isomerase gene lead to a defect in 3'-end formation of a pre-mRNA in Saccharomyces cerevisiae.PMID 9867817Read ↗

<i>PTF1</i> encodes an essential protein in <i>Saccharomyces cerevisiae</i>, which shows strong homology with a new putative family of PPIasesSemantic proximity Read ↗

A mutation in a methionine tRNA gene suppresses the prp2-1 Ts mutation and causes a pre-mRNA splicing defect in Saccharomyces cerevisiae.Semantic proximity Read ↗

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Conditional defect in mRNA 3' end processing caused by a mutation in the gene for poly(A) polymerase.Semantic proximity Read ↗

Mutational analysis of the Prt1 protein subunit of yeast translation initiation factor 3.Semantic proximity Read ↗

Vanishingly low levels of Ess1 prolyl-isomerase activity are sufficient for growth in Saccharomyces cerevisiae.Semantic proximity Read ↗

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