Article
The essential helicase gene RAD3 suppresses short-sequence recombination in Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Aug 1995
Bailis A M, Maines S, Negritto M T
Abstract excerpt
We have isolated an allele of the essential DNA repair and transcription gene RAD3 that relaxes the restriction against recombination between short DNA sequences in Saccharomyces cerevisiae. Double-strand break repair and gene replacement events requiring recombination between short identical or mismatched sequences were stimulated in the rad3-G595R mutant cells. We also observed an increase in the physical...
Topics
- Adenosine Triphosphatases
- Alleles
- Base Sequence
- Blotting, Southern
- DNA Damage
- DNA Helicases
- DNA Repair
- DNA, Fungal
- Genes, Fungal
- Genes, Lethal
- Genome, Fungal
- Models, Genetic