Poly-Electrophilic Sesquiterpene Lactones from<i>Vernonia amygdalina</i>: New Members and Differences in Their Mechanism of Thiol Trapping and in Bioactivity

Abstract excerpt

In addition to known compounds, the leaves of Vernonia amygdalina afforded the new sesquiterpene lactones 14-O-methylvernolide (2), 3'-deoxyvernodalol (6), and vernomygdalin (8). These and related compounds were evaluated for modulation of a series of thiol trapping-sensitive transcription factors (NF-κB, STAT3, and Nrf2), involved in the maintenance of the chronic inflammatory condition typical of human...

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