Article
An enzyme in yeast mitochondria that catalyzes a step in branched-chain amino acid biosynthesis also functions in mitochondrial DNA stability.
The EMBO journal - 3 Jul 1995
Zelenaya-Troitskaya O, Perlman P S, Butow R A
Abstract excerpt
The yeast mitochondrial high mobility group protein Abf2p is required, under certain growth conditions, for the maintenance of wild-type (rho+) mitochondrial DNA (mtDNA). We have identified a multicopy suppressor of the mtDNA instability phenotype of cells with a null allele of the ABF2 gene (delta abf2). The suppressor is a known gene, ILV5, encoding the mitochondrial protein, acetohydroxy acid reductoisomerase,...
Topics
- 2-Acetolactate Mutase
- Alleles
- Amino Acids, Branched-Chain
- Base Sequence
- Chromosome Mapping
- DNA, Fungal
- DNA, Mitochondrial
- DNA-Binding Proteins
- Enzyme Activation
- Fungal Proteins
- Gene Expression Regulation, Fungal