Article
Loss of the mitochondrial nucleoid protein, Abf2p, destabilizes repetitive DNA in the yeast mitochondrial genome.
Genetics - 1 Jan 2009
Sia Rey A, Carrol Stephanie, Kalifa Lidza, Hochmuth Christine, Sia Elaine A
Abstract excerpt
Loss of Abf2p, an abundant mitochondrial nucleoid-associated protein, results in increased mitochondrial frameshifts and direct-repeat mediated deletions but has no effect on the rate of mitochondrial point mutations. The instability of repeated sequences in this strain may be linked to the loss of mitochondrial DNA in abf2-Delta strains.
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