Article
Synergistic trophic actions on rat basal forebrain neurons revealed by a synthetic NGF/BDNF chimaeric molecule.
The European journal of neuroscience - 1 Apr 1995
Friedman W J, Black I B, Persson H, Ibáñez C F
Abstract excerpt
Basal forebrain cholinergic neurons, which degenerate in Alzheimer's disease, respond to multiple trophic factors, including the neurotrophins, nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). This dual responsiveness prompted us to investigate the effects of a synthetic ch...
Topics
- Animals
- Basal Ganglia
- Brain-Derived Neurotrophic Factor
- Cell Survival
- Cells, Cultured
- Female
- Histocytochemistry
- Nerve Growth Factors
- Nerve Tissue Proteins
- Neurons
- Nodose Ganglion
- Parasympathetic Nervous System
- Phenotype
- Phosphorylation
- Pregnancy
- Prosencephalon
- Protein Conformation
- Protein-Tyrosine Kinases