The inductive effect of a human DNA sequence (HALF1) on the differentiation of a variant rat hepatoma cell (C2) is restricted to episomal forms of the molecule.

doi:10.1242/jcs.108.4.1703

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The inductive effect of a human DNA sequence (HALF1) on the differentiation of a variant rat hepatoma cell (C2) is restricted to episomal forms of the molecule.

Journal of cell science - 1 Apr 1995

Ng K H, Maigné J, Deschatrette J

Abstract excerpt

HALF1, a 4.3 kb human DNA sequence, was originally identified as a double-stranded, closed-circular DNA molecule in revertants from a dedifferentiated rat hepatoma cell (C2) transfected with human liver DNA. Here we report its specific properties in inducing the transition to the hepatic phenotype. (i) In vitro recircularized HALF1 induces reversion after a minimum time lag of 7 days post-transfection. (ii) After...

Topics

Animals
Blotting, Southern
Cell Differentiation
DNA Probes
DNA, Circular
Electroporation
Humans
Kinetics
Liver
Liver Neoplasms, Experimental
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmids

Rats

Restriction Mapping

Time Factors

Transcription, Genetic

Transfection

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 7615687
DOI: 10.1242/jcs.108.4.1703

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7615687-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

The inductive effect of a human DNA sequence (HALF1) on the differentiation of a variant rat hepatoma cell (C2) is restricted to episomal forms of the molecule.PMID 7615687Read ↗

Expression and localization of hepatocyte domain-specific plasma membrane proteins in hepatoma x fibroblast hybrids and in hepatoma dedifferentiated variants.Semantic proximity Read ↗

Constancy of expression of the protein kinase A regulatory subunit R1 alpha in hepatoma cell lines of different phenotypes.Semantic proximity Read ↗

Genomic and Molecular Maps of Stemness and Malignant Regulatory SignaturesSemantic proximity Read ↗

What Is Extrachromosomal Circular DNA and What Does It Do?Semantic proximity Read ↗

Human Induced Pluripotent Stem Cells in HepatologySemantic proximity Read ↗

LINE-1 retrotransposons: modulators of quantity and quality of mammalian gene expression?Semantic proximity Read ↗

Epigenetic regulation of cancer stem cells in liver cancer: Current concepts and clinical implicationsSemantic proximity Read ↗

Spontaneous retrotranspositions in normal tissues are rare and associated with cell-type-specific differentiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.