Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytochrome b-245 of the neutrophil superoxide-generating system contains two nonidentical hemes. Potentiometric studies of a mutant form of gp91phox.

The Journal of biological chemistry - 21 Jul 1995

Cross A R, Rae J, Curnutte J T

Abstract excerpt

Analysis of potentiometric titrations of the cytochrome b-245 from a X+ chronic granulomatous disease patient with an Arg54 --> Ser mutation in gp91phox indicates that the mutant form of the cytochrome contains two nonidentical hemes with midpoint potentials of Em7 = -220 and Em7 = -300 mV. In th...

Topics

Cytochrome b Group
Heme
Humans
Mutation
Neutrophils
Potentiometry
Superoxides

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7615499
DOI: 10.1074/jbc.270.29.17075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7615499-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytochrome b-245 of the neutrophil superoxide-generating system contains two nonidentical hemes. Potentiometric studies of a mutant form of gp91phox.PMID 7615499Read ↗

A variant X-linked chronic granulomatous disease patient (X91+) with partially functional cytochrome b.Semantic proximity Read ↗

Molecular analysis in three cases of X91- variant chronic granulomatous disease.Semantic proximity Read ↗

Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease.Semantic proximity Read ↗

Mutation at histidine 338 of gp91(phox) depletes FAD and affects expression of cytochrome b558 of the human NADPH oxidase.Semantic proximity Read ↗

Functional analysis of two-amino acid substitutions in gp91 phox in a patient with X-linked flavocytochrome b558-positive chronic granulomatous disease by means of transgenic PLB-985 cells.Semantic proximity Read ↗

The gp91phox component of NADPH oxidase is not the voltage-gated proton channel in phagocytes, but it helps.Semantic proximity Read ↗

Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding.Semantic proximity Read ↗

Identification of NOX2 regions for normal biosynthesis of cytochrome b558 in phagocytes highlighting essential residues for p22phox binding.Semantic proximity Read ↗

Absence of both subunits of cytochrome b558 in the UM384 cell line relative to the inability to generate superoxide anions.Semantic proximity Read ↗

Impact of mutations on the midpoint potential of the [4Fe-4S]+1,+2 cluster and on catalytic activity in electron transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO).Semantic proximity Read ↗

Mutagenic, electrochemical, and crystallographic investigation of the cytochrome b5 oxidation-reduction equilibrium: involvement of asparagine-57, serine-64, and heme propionate-7.Semantic proximity Read ↗

Analysis of glycosylation sites on gp91phox, the flavocytochrome of the NADPH oxidase, by site-directed mutagenesis and translation in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.